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发明公开
CN102690846A 谷氨酸生物固相酶催化合成γ-氨基丁酸的方法 无效 - 驳回

谷氨酸生物固相酶催化合成γ-氨基丁酸的方法
摘要：
本发明提供了一种谷氨酸生物固相酶催化合成γ-氨基丁酸的方法，包括以下步骤：（1）将底物谷氨酸溶液与固相酶催化合成生成γ-氨基丁酸溶液，再通过过滤或离心分离生物固相酶与反应液；（2）γ-氨基丁酸水溶液活性炭脱色后，真空薄膜浓缩得γ-氨基丁酸浓溶液；（3）γ-氨基丁酸浓溶液加入95%酒精，析出γ-氨基丁酸白色沉淀结晶，离心分离，真空干燥得白色γ-氨基丁酸粉末。该工艺反应专一、产率高、纯度好、周期短、能耗低、适合工业化生产。
摘要（英）：

The invention provides a method for catalytically synthesizing gamma-aminobutyric acid from a glutamate biological solid-phase enzyme, The method comprises the following steps: (1) catalytically synthesizing substrate glutamic acid solution with solid-phase enzyme to generate gamma-aminobutyric acid solution, and then filtering or centrifugally separating the biological solid-phase enzyme from reaction solution; (2) after the activated carbon fading of the gamma-aminobutyric acid solution, concentrating the obtained product in vacuum by a thin film to obtain concentrated gamma-aminobutyric acid solution; and (3) adding 95% alcohol in the gamma-aminobutyric acid solution, crystallizing, centrifugally separating and drying the precipitated gamma-aminobutyric acid white precipitate in vacuum to obtain white gamma-aminobutyric acid powder. The process has the advantages of special reaction, high yield and purity, short period and low energy consumption and is suitable for industrial production.

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