The invention relates to the technical field of spraying equipment, in particular to an automatic spray gun regulation frame on the spraying equipment, which comprises a base, a transverse frame which is driven by a hoisting mechanism on a column to lift and descend, a rotary frame and a gun seat for installing a spray gun, wherein the column is arranged on the base; the transverse frame is cross-installed on the column of the base; the rotary frame is installed on a sliding block which can move along the axial direction of the transverse frame, and can be driven by a drive mechanism which is installed on the sliding block to rotate; and the gun seat can be rotatably installed on the rotary frame. The automatic spray gun regulation frame provided in the invention can realize the up and down, back and forth and rotary adjustment of the spray gun, moreover, a motor is adopted to drive and control so that full-automatic control is realized, the spray gun is enabled to spray the whole working face without dead angles, so the adaptability of the spraying equipment is increased, the automatic spray gun regulation frame has a simple structure, is scientific and reasonable, easy to produce, low in cost, and very convenient to operate, use and maintain, and is in accordance with the industrial utilization, so the operating ratio and operability of the spraying equipment are greatly improved.