The invention relates to the technical field of directional well wired skew cables in petroleum drilling, and discloses a directional well wired skew cable fixing anti-collision device which comprises a body and a connection end, wherein the upper end of the connection end is fixed with the lower end of the body; a groove, the axial line of which is along the vertical direction, is arranged on the outer side of the body; an internal thread mounting groove is arranged at the upper part of the body; through holes which are communicated with the internal thread mounting groove are arranged in the body and the connection end; and an external thread is arranged on the outer side of the connection end. The well wired skew cable fixing anti-collision device is reasonable and compact in structure, convenient for use and capable of preventing easy cable breakage in the directional operation of a wired skew instrument through the cooperation of the connection end and the body, and has the characteristics of being easy for manufacturing and simple in operation, so that the production cost is reduced and the work efficiency is improved.