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发明公开
CN102731336A 利奈唑胺中间体及合成利奈唑胺的方法 有权 转让

利奈唑胺中间体及合成利奈唑胺的方法
摘要：
本发明涉及化学领域，公开了利奈唑胺的中间体及其制备方法以及合成利奈唑胺的方法。本发明提供的利奈唑胺中间体，其结构如式F2所示，易于制备。本发明还提供式F2所示化合物的制备方法，由(S)-N-(3-氯-2-羟基-1-丙基)乙酰胺与式F4所示化合物进行缩合反应制备。本发明提供的式F2所示化合物的制备方法以及合成利奈唑胺的方法，反应体系温和，副反应少，产品收率高，具有工业化前景。
摘要（英）：

The present invention relates to the chemical field, and discloses a linezolid intermediate and a preparation method thereof, and a synthetic method of linezolid. The linezolid intermediate provided by the present invention has a structure shown as a formula F2, and is easy for preparation. The invention also provides the preparation method of the compound shown as the formula F2; and the compound is prepared from condensation reaction of (S)-N-(3-chloro-2-hydroxy-1-propyl) acetamide and a compound shown as a formula F4. The preparation method of the compound shown as formula F2 and the synthetic method of linezolid provided by the present invention have advantages of mild reaction system, few side reaction, high product yield and industrialization prospects. The formulas F2 and F4 are shown in the description.

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