The present invention relates to cyclized berberine derivatives, a preparation method and uses thereof. The present invention specifically relates to compounds represented by a formula I or a pharmaceutically-acceptable salt or a solvate thereof, wherein X is a halogen, R is selected from hydrogen, C1-6 alkyl, phenyl substituted C1-6 alkyl, C1-18 alkylacyl, benzoyl, benzenesulfonyl, and 3,4-C1-3alkylidene dioxybenzoyl, the phenyl is optionally substituted by 1-4 substituents selected from halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxy, C1-4 alkyl acylamino. The compounds of the present invention have beneficial physiological activities.