The invention discloses an herbicide composition containing sulfosulfuron and clodinafop-propargyl. The herbicide composition comprises a first active ingredient of sulfosulfuron and a second active ingredient of clodinafop-propargyl, wherein the mass ratio of the first active ingredient to the second active ingredient is (1:15)-(10:1). The composition can be prepared into agriculturally allowed water dispersible granules, wettable powder, missible oil and suspension. The herbicide composition is reasonable in component, good in herbicide effect and low in dosage cost, the activity and the herbicide effect are not simply superposed by the activities of the components, and compared with the existing single preparation, the herbicide composition has the advantages of being obvious in herbicide effect, obvious in synergistic effect and high in safety, meeting the safety requirement of the pesticide preparation, and achieving high herbicide activity on the weeds in a wheat paddock.