The invention provides a solution with ponazuril and solves the problem of inconvenience in medicine feeding in veterinary clinical application caused by low water-solubility of the ponazuril in the prior art. According to the technical scheme, the solution with ponazuril comprises the following components of (a) 0.5 to 3 percent of ponazuril, (b) 2 to 20 percent of cosolvent, (c) 1 to 10 percentof emulsifier, (d) 0.01 to 0.5 percent of antioxygen, (e) 1 to 10 percent of acid-base adjustment agent and (f) 50 to 95 percent of solvent, wherein the percentage is W/V; the unit of W is g; and theunit of V is ml. The invention also provides a method for preparing the solution. The solution with the concentration of between 0.5 to 3 percent according to a clinical requirement can be prepared and mixed with water according to any proportion and has the characteristic of convenience in clinical medicine feeding.