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发明公开
CN102775366A 3-(5-甲氧基-1,5-二氧代戊基)-(4S)-苯基噁唑烷-2-酮的制备方法 无效 - 撤回

3-(5-甲氧基-1,5-二氧代戊基)-(4S)-苯基噁唑烷-2-酮的制备方法
摘要：
本发明公开了一种3-(5-甲氧基-1，5-二氧代戊基)-(4S)-苯基噁唑烷-2-酮的制备方法，所述方法包括步骤：(1)将戊二酸酐和甲醇混合、反应，得到混合物1，所述混合物1中含有戊二酸单甲酯和戊二酸；(2)将混合物1和二氯甲烷混合后用饱和氯化钠溶液洗涤，得到戊二酸单甲酯；(3)将戊二酸单甲酯和氯化亚砜混合、反应得到4-氯甲酰基丁酸甲酯；和(4)在0-5℃，将4-氯甲酰基丁酸甲酯在3-3.5小时内和(S)-4-苯基噁唑烷酮混合，缩合得到3-(5-甲氧基-1，5-二氧代戊基)-(4S)-苯基噁唑烷-2-酮。
摘要（英）：

The invention discloses a preparation method for 3-(5-methoxy-1,5-dioxopenyl)-(4S)-phenyloxazolidin-2-one. The method comprises the following steps: (1) mixing and reacting glutaric anhydride and methanol to obtain mixture 1 which contains monomethyl glutarate and glutaric acid; (2) mixing the mixture 1 with dichloromethane and rinsing an obtained mixture with an saturated sodium chloride solution to obtain monomethyl glutarate; (3) mixing and reacting monomethyl glutarate with thionyl chloride to obtain methyl 4-(chlorofomyl)butyrate; and (4) mixing methyl 4-(chlorofomyl)butyrate with (S)-4-phenyloxazolidinone at a temperature of 0 to 5 DEG C within 3 to 3.5 h and carrying out condensation to obtain 3-(5-methoxy-1,5-dioxopenyl)-(4S)-phenyloxazolidin-2-one.

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