The invention relates to a compound pure Chinese medicine composition for treating bovine ephemeral fever and a preparation method of the compound pure Chinese medicine composition. The composition is prepared by mixing the following components in part by weight: 25-45 parts of plaster, 25-35 parts of platycodon root, 25-35 parts of cape jasmine fruit, 15-35 parts of menthol, 15-35 parts of mulberry leaf, 15-35 parts of pepper stem, 25-45 parts of licorice, 25-45 parts of dried orange peel, 15-45 parts of ephedra, and 15-45 parts of baical skullcap root. The compound pure Chinese medicine composition has the benefits of reasonable formula, simplicity in preparation, no toxic or side effect, no pollution, no medicinal residue, no drug tolerance, ultrafine particles, high bioavailability and very remarkable curative effect, and has a specially good effect on treating bovine ephemeral fever, which is proved clinically.