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发明公开
CN102807613A 具有趋化活性的分泌蛋白及其医药用途 无效 - 撤回

具有趋化活性的分泌蛋白及其医药用途
摘要：
本发明提供了具有白细胞和肿瘤细胞趋化功能的SEQ ID NO：1所示氨基酸序列的蛋白(C17ORF87分泌蛋白)，编码该蛋白的多核苷酸，以及含有多核苷酸的基因工程载体。还涉及药物组合物，含有所述蛋白或多核苷酸、基因工程载体和/或宿主细胞，及药物可接受的盐、载体或赋形剂。另外还涉及体外检测所述蛋白或多核苷酸表达水平变化的方法。还有所述蛋白或多核苷酸能够用于预防和/或治疗病毒感染、过敏性疾病、炎症反应、移植排斥、脑部疾病、自身免疫病、肿瘤转移、免疫调节、干细胞增殖分化、骨质疏松症、肥胖和胰岛素抵抗，以及用于商品化试剂研究上述病状。还涉及以所述蛋白或多核苷酸作为靶开发化合物、抗体、多肽药物和商品化试剂。
摘要（英）：

The invention provides protein (C17ORF87 secreted protein) with a white blood cell and tumor cell chemotactic activity and the amino acid sequence shown as SEQ ID NO.1, polynucleotide for coding the protein and a genetic engineering carrier containing the polynucleotide. The invention further relates medicine compositions containing the protein, the polynucleotide, the genetic engineering carrier and/or host cells and salts, carriers or excipients acceptable to medicines, relates to a method for in vitro detection of expression level changes of the protein or the polynucleotide, applications of the protein or the polynucleotide to prevention and/or treatment of virus infection, allergic diseases, inflammatory reactions, transplant rejection, cerebral diseases, autoimmune diseases, tumor metastasis, immunoregulation, stem cell proliferation and differentiation, osteoporosis, fat and insulin resistance and application of the protein or the polynucleotide to commercialized reagents for studying the symptoms, and relates to usage of the protein or the polynucleotide as target development compounds, antibodies, polypeptide drugs and commercialized reagents.

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