The invention discloses a composite grouting reinforcement anti-seepage treatment technology. The composite grouting reinforcement anti-seepage treatment technology comprises the steps as follows: drilling, washing the drilled holes, carrying out water pressure test, carrying out cement grouting, carrying out non-grouting section isolation, draining, carrying out chemical grouting, carrying out mortar closing, displacing and sealing the holes. When the water permeable rate before grouting is more than 11 mu, the wet levigated cement grouting process is carried out; when the water permeable rate before grouting is less than 11 mu, the chemical grouting process is carried out; or, when the water permeable rate before grouting is more than 1 L mu, the wet levigated cement grouting process is ended, the chemical grouting process is carried out after the hole cleaning process is finished, and a dual-component epoxy resin grouting material is adopted in the chemical grouting process. According to the composite grouting reinforcement anti-seepage treatment technology, the grouting process is controlled and the grouting technology is improved by cement and chemical compound grouting combination, in particular the mortar maintaining operation time and the grouting material temperature are controlled to obtain high permeability, the design requirement in the practical use of engineering is met, the technical requirements of economy, quickness, reliability and stability are satisfied, and meanwhile, the solidifying time of later mortar is greatly shortened. The design requirement of mechanical property index can be met in 28 days after compound grouting by the technology.