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发明授权
CN102816763B 特异性结合于疟原虫乳酸脱氢酶pLDH的DNA适体 有权 转让

特异性结合于疟原虫乳酸脱氢酶pLDH的DNA适体
摘要：
本发明公开了一种特异性结合于疟原虫乳酸脱氢酶pLDH的DNA适体、含有所述DNA适体的用于诊断疟疾的组合物以及使用所述DNA适体的用于疟疾的诊断试剂盒。由于在特异性和稳定性上比常规用于诊断疟疾的抗体更为优越，根据本发明的特异性结合于疟原虫乳酸脱氢酶pLDH的DNA适体可制成以高敏感度和高准确度测定pLDH水平的生物传感器，这大大有助于疟疾的诊断准确性。
摘要（英）：

Disclosed herein are a DNA aptamer specifically binding to pLDH (Plasmodium Lactate Dehydrogenase), a composition for the diagnosis of malaria, comprising the same, and a diagnostic kit for malaria using the same. Superior in specificity and stability to antibodies which are conventionally used to diagnose malaria, the DNA aptamers specifically binding to pLDH (Plasmodium Lactate Dehydrogenase) in accordance with the present invention can be developed into biosensors which determine pLDH levels with high sensitivity and accuracy, greatly contributing to the diagnostic accuracy of malaria.

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