A method of selecting the positioning method(s) used to respond to given positioning requests uses historical performance data reflecting the actual performance yielded by one or more of the positioning methods that are generally available for selection. As a non-limiting example, a positioning node maintains or otherwise has access to historical data reflecting the QoS obtained for at least some of the positioning methods supported by the node. Correspondingly, the node compares the QoS requirements associated with an incoming positioning request to the historical performance data, to identify the positioning method(s) that appear to best satisfy the requirements. The positioning node therefore selects the “best” method(s) for responding to a positioning request, not based on “generic” performance characteristics of those methods, but rather based on observed real-world performance of those methods, as applicable to the particular operating environment (radio environment) in which the positioning methods are carried out.