The invention relates to an oil well sealing device, and in particular relates to an automatic deviation adjusting wellhead sealing device. The technical scheme adopted by the invention is as follows: the automatic deviation adjusting wellhead sealing device mainly comprises a connector, a locking cap, a pushing cap, a lower packing, an upper filler box, an upper packing, a gland and a pressing cap, wherein the lower part of the connector is connected with the lower part of the locking cap through a thread, the upper part of the connector is provided with the lower packing; the upper part of the locking cap and the lower end of the pushing cap are connected through a thread; the upper part of the pushing cap is fixedly provided with the upper filter box, the upper packing is fixed in the upper filler box, the top of the upper packing is fixedly provided with the gland, the pressing cap is connected with the upper filler box by virtue of a w thread, and the upper part of the upper filler box is provided with the pressing cap. The automatic deviation adjusting wellhead sealing device disclosed by the invention has the beneficial effects that the service life of the sealing device is prolonged, the production efficiency is improved, the crude oil loss is avoided, and the production yield is improved.