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发明公开
CN102844111A 生产色谱介质的方法 失效 - 放弃专利权

生产色谱介质的方法
摘要：
本发明涉及生产具有改进的压力-流动性质的色谱介质的方法和方式。更确切地，本发明涉及双峰粒径分布和层功能化用作改变色谱介质的压力-流动性质的方式。本发明涉及用于生产具有改进的压力-流动性质的色谱介质的方法，该方法包含使包含内核和外功能化壳/盖的大珠粒/颗粒与较小珠粒/颗粒混合，其中大珠粒和小珠粒的粒径比率：[大颗粒的D50V/小颗粒的D50V]>1.2，且其中柱中的大珠粒和小珠粒的体积比：[大珠粒的总体积/珠粒总体积]的范围在0.05-0.9。
摘要（英）：

The present invention relates to a method and means to produce chromatography media having improved pressure-flow properties. More closely, the invention relates to bimodal particle size distribution and the use of layer functionalisation as means to change pressure-flow properties of chromatography media. The invention relates to a method for production of chromatography media having improved pressure-flow properties, comprising mixing large beads/particles, comprising an inner core and an outer functionalized shell/lid, with smaller beads/particles, wherein the ratio of the particle size of large and small beads: [D50V for large particles/ D50V for small particles] >1.2, and wherein the volume ratio of large and small beads in the column: [Total volume of large beds/Total volume beads] is in the range 0.05 -0.9.

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