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发明授权
CN102871968B 西地那非大黄酸盐药物颗粒的制备及该颗粒吸入式气雾剂的制备 失效 - 权利终止 转让

西地那非大黄酸盐药物颗粒的制备及该颗粒吸入式气雾剂的制备
摘要：
本发明提供了西地那非大黄酸盐的药物颗粒制备及该颗粒的吸入式气雾剂的制备。西地那非与大黄酸作用形成酸盐，所述酸盐与环糊精、多糖类、聚乳酸类中的一种或多种通过超临界流体结晶技术制备得到形成大小可控的药物颗粒，所制得的药物颗粒粒径可在0.5μm与5μm之间。这种药物颗粒可以制成定量吸入气雾剂、粉雾剂以及其他生理学上可以接受的其他制剂类型。
摘要（英）：

The invention provides a preparation method for sildenafil rhubarb hydrochloric acid medicine granules and a preparation method for suction type aerosol of the gradules. Sildenafil reacts with rheinic acid to form an acid salt, size-controllable medicine granules are formed by preparing the acid salt and cyclodextrin, one or more than one of polysaccharides and polylactic acids via a supercritical fluid crystallization technology, and the diameter of the prepared medicine granules is 0.5-5 microns. The medicine granules can be prepared to quantitative suction type aerosol and powder inhalations as well as other types of preparations capable of being accepted physiologically.

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