The invention discloses an isolating belt pressure sealing clamp, which is used in the technology of injecting belt pressure sealing for treating that the wall thickness of a straight pipe section, a tee and an elbow part in an operating pipeline are obviously reduced or the leakage defect size is larger, the flange strength is insufficient in linear sealing structure flanges and connecting bolts caused by various reasons, and the leakage accident is caused by the compound material pipelines with insufficient rigidity. The isolating belt pressure sealing clamp includes a clamp main body, an annular injecting groove, an axial injecting groove, an isolating sealing cavity and injecting holes, wherein the annular injecting groove, the axial injecting groove and the injecting holes are formed in the clamp main body; the leakage defect part is covered in the isolating sealing cavity to form isolating effect with the annular injecting groove and the axial injecting groove, so that the leakage defect part is not subjected to the damage or breakage of the external force; by arranging the injecting holes in the annular injecting groove and the axial injecting groove to inject sealant, the sealant is strictly limited in the injecting groove to flow and be filled, and is free from the direct contact with the leakage defect part; as the stress area is stripped, the whole stress on the clamp and the whole stress on the leaked pipeline are obviously reduced; and when the working sealing specific pressure of the sealant injected into the injecting groove is bigger than the pressure of the leaked medium, the purpose of belt pressure sealing is achieved.