The invention discloses a materia medica medicated soap composition and a preparation method thereof. The materia medica medicated soap composition is prepared mainly through materia medica raw materials of clove, dahurian angelica, cortex cinnamomi, mulberry leaf, chryanthemum flower, dried orange peel, licorice, turmeric, honeysuckle flower, elsholtzia, dandelion, dark plum, purple common perilla, cape jasmine, Chinese wolfberry root-bark, wild chrysanthemum flower, sandal, agastache, auckandia root, Chinese violet, muskroot-like semiaquilegia root, milk vetch, honey, olive oil, dairy salt, red wine and the like which are not only food but also medicaments as well as a proper amount of montmorillonite according to certain mix proportions by weight, and has the functions of skin cleaning and bacteriostasis and immunity regulation.