The invention relates to a preparation method of toilet soap, in particular to a preparation method of cosmetic crease-resist toilet soap, which belongs to the field of daily toiletries. The cosmetic crease-resist toilet soap is prepared by the following raw materials by weight percent: 5-20 percent of cocoamidopropyl hydroxy sulfo betaine, 2-10 percent of glycol distearate, 0.5-5 percent of triethanolamine, 0.5-5 percent of methyl isopropyl thiazolinone, 2-5 percent of nanoscale collagen, 2-5 percent of amino acid, 0.5-2 percent of vitamin E, 0.5-2 percent of ursolic acid loquat leaf extract, 2-10 percent of divaricate saposhnikovia root, 2-10 percent of angelica root and 2-5 percent of aconite typhonium. The preparation method of the cosmetic crease-resist toilet soap is simple in processing steps and reasonable in material selection, and the produced toilet soap has better skin care and strong disinfection functions, and enables users to satisfactorily absorb the nutrient ingredients thereof, so as to achieve the effects of maintaining beauty and keeping young.