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发明公开
CN102911940A 特异性抑制NK细胞受体KIR3DL1的小核酸干扰分子及其应用 失效 - 权利终止

特异性抑制NK细胞受体KIR3DL1的小核酸干扰分子及其应用
摘要：
本发明公开了特异性抑制NK细胞受体KIR3DL1的小核酸干扰分子及其应用。特异性抑制NK细胞受体KIR3DL1的小核酸干扰分子，其靶向的KIR3DL1的mRNA的genbank登录号为NM_013289。通过大量实验发现：本发明siRNA片段可以明显抑制NK细胞膜的KIR3DL1受体的表达，经过各种化学修饰的siRNA具有相同的抑制KIR3DL1表达的效果。抑制KIR3DL1表达以后可以使NK细胞中IFN-γ和TNF-α细胞因子的表达显著升高。同时，转染siRNA后可以显著增强NK细胞的杀伤功能。因此，特异性抑制NK细胞受体KIR3DL1的小核酸干扰分子可以在制备抗艾滋病药物中应用。
摘要（英）：

The invention discloses a small ribonucleic acid interference molecule for specifically inhibiting an NK (Natural Killer) cell receptor KIR3DL1 and an application of the small ribonucleic acid interference molecule. The genbank login number of the mRNA of the targeted KIR3DL1 of the small ribonucleic acid interference molecule for specifically inhibiting the NK cell receptor KIR3DL1 is NM_013289. A large amount of experiments show that the siRNA fragment can remarkably inhibit the expression of the receptor KIR3DL1 of an NK cell membrane, and the siRNA subjected to various chemical modifications has the same effect of inhibiting the expression of the receptor KIR3DL1. The expression level of IFN-gamma and TNF-alpha cell factors in an NK cell can be remarkably increased after the expression of the receptor KIR3DL1 is inhibited. Meanwhile, the killing activity of the NK cell can be remarkably enhanced after the siRNA is transfected. Therefore, the small ribonucleic acid interference molecule for specifically inhibiting the NK cell receptor KIR3DL1 can be applied to preparation of anti-aids drugs.

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