Disclosed is a pipe type circulation-based reaction apparatus which comprises two or more fluid supply passages formed by a multi-layered tube for supplying two or more types of fluids to be used for reaction; a reaction flow passage which has an annular cross section and is capable of reacting said fluids while causing the same to circulate; and a fluid discharge passage for discharging resection products. In order that the fluid supply passages may communicate with the inlet to the reaction flow passage, the fluid supply passages are connected along a circumferential tangent direction of the annular reaction flow passage or along a direction intersecting the circumferential surface thereof at right angles. Furthermore, the fluid discharge passage is connected to the outlet of the reaction flow passage in such a way as to establish communication.