The present invention relates to a device (2) for automatically quantifying intravascular embolization success, comprising a registration unit (4) adapted for registering a first image and a second image, a segmentation unit (6) adapted for segmenting a tissue of interest in the first image and in the second image and an evaluation unit (8) for evaluating a deviation of perfusion of the tissue of interest by comparing the first image and the second image. The first image is obtained before an interventional treatment, whereas the second image is obtained after such a treatment. Evaluating may comprise comparing the segments of the first and the second images and thus providing a quantitative measure for a perfusion deviation of the tissue, e.g. the perfusion deviation of a tumorous tissue before and after an embolization treatment.