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发明公开
CN102924249A 番茄红素中间体2-甲基-3,3-二甲氧基-1-丙醛的制备方法 有权

番茄红素中间体2-甲基-3,3-二甲氧基-1-丙醛的制备方法
摘要：
本发明提供了一种番茄红素的中间体2-甲基-3，3-二烷氧基-1-丙醛的制备方法，所述方法包括如下步骤：步骤1)：式(2)所示的3，3-二甲氧基-1-丙烯在有机溶剂及环氧化试剂存在下在0～30℃温度下进行环氧化反应得到式(3)所示的2，3-环氧基-2-甲基-1-醛缩二甲醇；步骤2)：式(3)所示的2，3-环氧基-2-甲基-1-醛缩二甲醇在有机溶剂及路易斯酸催化下在-30～0℃温度条件下进行重排反应得到式(1)所示的2-甲基-3，3-二甲氧基-1-丙醛。本发明的工艺路线简捷，成本低，极具工业价值。
摘要（英）：

The invention provides a preparation method of a lycopene intermediate 2-methyl-3,3-dimethoxy-1-propionaldehyde. The method comprises the following steps: 1, carrying out an epoxidation reaction of 3,3-dimethoxy-1-propylene having a structure represented by formula (2) in the presence of an organic solvent and an epoxidation reagent at 0-30DEG C to obtain 2,3-epoxy-2-methyl-1-aldehyde dimethyl acetal having a structure represented by formula (3); and 2, carrying out a rearrangement reaction of the 2,3-epoxy-2-methyl-1-aldehyde dimethyl acetal of the formula (3) in the organic solvent under the catalysis of a Lewis acid at -30-0DEG C to obtain the 2-methyl-3,3-dimethoxy-1-propionaldehyde having a structure represented by formula (1). The preparation method has the advantages of simple technological route, low cost, and great industrial values.

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