The invention relates to a regional power grid fault isolation and recovery method. The method comprises the following steps of: firstly, determining the phase of a circuit breaker which does not work normally due to faults; performing three-phase tripping on a faulty circuit breaker through failure protection time delay; meanwhile, tripping the phase of the corresponding fault phase of a circuit breaker adjacent to the circuit breaker in a time delay way; judging whether each phase of current of the faulty circuit breaker is zero, if so, automatically separating disconnecting links at both sides of the faulty circuit breaker; and finally automatically reclosing the corresponding phases of other circuit breakers adjacent to the faulty circuit breaker so as to achieve the action of automatically and quickly recovering system power supply. According to the invention, the disconnecting links of the faulty circuit breaker are automatically pulled open after failure protection action information is acquired according to the regional power grid network protection control system, the circuit breaker is switched from an operating state to a cold standby state, and afterwards, the protection control system quickly recovers other circuit breakers in the hot standby state so as to achieve the purpose of automatically and quickly recovering system power supply.