A device comprising an elongated conduit comprising further at least an upper profile and at least a lower profile is disclosed. The upper and lower profiles being relatively displaceable such that when a distal part of the conduit is deployed between two regions of tissue, a spacing between an upper distal surface of the upper profile and a lower distal surface of the lower profile can be varied, thereby opening a space between the two regions of tissue, and wherein the upper and lower profiles are further configured so as to define therebetween a working channel to provide access to the space between the two regions of tissue through the conduit.