The invention provides artificial forsterite sand and application thereof in preparation of a forsterite brick. Industrial residue with magnesium oxide and silicon dioxide is adopted as a raw material, the forsterite sand is prepared by pre-synthesis and pre-reaction and is then used for production of the forsterite brick, that is, mixture is prepared with the molar ratio 2:1 of MgO/SiO2, a blank is prepared by mixing and is dried and sintered to prepare the forsterite sand, the prepared forsterite sand is mixed to prepare a blank, and the blank is dried and sintered to prepare the forsterite brick. The forsterite brick prepared according to the method has the advantages of complete binder phase, complete crystal growth, good high-temperature performance and strong resistance against chemical erosion of sulfur and alkali.