The invention provides a non-dead-zone control optimizing method based on an immune algorithm for an inverter. On the basis of various methods for reducing or eliminating dead-zone effects, a new three-level dead-zone eliminating method directing at a single-phase full bridge inverter is provided. Under the condition that precise electrical polarity detection is not required, a switch sequence is determined by dividing a reference current area. The non-dead-zone control optimizing method can achieve seamless transition non-dead-zone control near a current zero crossing point and among all areas. A pulse-width modulation (PWM) control sequence meeting a dead-zone eliminating method requirement is optimized by means of the immune algorithm, and output waveform quality of the inverter is improved. Compared with a conventional control strategy, the non-dead-zone optimal PWM control sequence not only can effectively remove dead-zone effects, but also can reduce total harmonic distortion (THD) of the output waveform of the inverter remarkably.