The invention discloses a medicine composition capable of clearing heat and removing toxicity, and a preparation method of a stock solution of the medicine composition. The medicine composition is prepared by the following components by a certain weight ratio: cholic acid, honeysuckle, gardenia jasminoides ellis and isatis root; and the medicine composition can be prepared into any forms, and injection preparation is preferable. Compared with conventional Qingkailing compound injection, the medicine composition disclosed by the invention has the characteristics of being remarkable in treatment effect and higher in safety.