The invention discloses an IPv6 (internal protocol version 6) DNS (domain name server) address distribution and acquisition method and device. The method comprises the following steps: using a wireless data card to receive request information from a mainframe, wherein the request information is used for asking for acquiring the IPv6 DNS address; and distributing the IPv6 DNS address by the wireless data card to the mainframe through an application interface between the mainframe and the wireless data card. Through the IPv6 DNS address distribution and acquisition method and device provided by the invention, the problems that the mainframe of IPv6 equipment in the related technology cannot acquire the IPv6 DNS address or that a service system architecture needs to be changed much to acquire the IPv6 DNS address are solved, so that the DNS address can be simply and automatically distributed to the IPv6 equipment without changing the system architecture, not only is the cost relatively low, but also the IPv6 networking and data transmission functions of mobile wireless data communication equipment are improved to a certain extent.