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CN103014138A 一种判定中国汉族人IL-12b基因rs6887695单核苷酸多态性与系统性红斑狼疮相关性的方法 无效 - 驳回

一种判定中国汉族人IL-12b基因rs6887695单核苷酸多态性与系统性红斑狼疮相关性的方法
摘要：
本发明公开了一种判定中国汉族人IL-12b基因rs6887695单核苷酸多态性与系统性红斑狼疮相关性的方法。本发明通过HRMA结合非标记探针，成功地区分了所有的基因型，结果显示，在中国汉族系统性红斑狼疮患者中，IL-12b与系统性红斑狼疮的发病风险度相关，也与关节炎和自身抗体的产生相关。为进一步研究系统性红斑狼疮的发病机制提供了重要的依据。
摘要（英）：

The invention discloses a method for determining correlation between a single nucleotide polymorphism rs6887695 of IL-12b gene of Chinese Han people and systemic lupus erythematosus. Through the combination of high resolution melting analysis (HRMA) and a non-labeled probe, all genotypes are distinguished successfully. A result obtained by the method shows that based on Chinese Han people suffering from systemic lupus erythematosus, the IL-12b gene is related to a systemic lupus erythematosus incidence risk and also is related to arthritis and autoantibody production. The method provides an important basis for further research on systemic lupus erythematosus pathogenesis.

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