The invention discloses a biomedical heating composite and a preparation method thereof. The preparation method comprises the following steps of: washing the surfaces of a nichrome bar and a titanium or titanium alloy pipe till new metal surfaces are exposed; then, sleeving the nichrome bar in the titanium or titanium alloy pipe and putting the titanium or titanium alloy pipe in an explosive cladding sleeve to realize accurate positioning, wherein a gap between the titanium or titanium alloy pipe and the nichrome bar is 0.5-2mm; and uniformly putting explosive charges which are 5-20mm thick between the outer side of the titanium or titanium alloy pipe and the explosive cladding sleeve, manufacturing a biomedical heating composite by an explosive cladding process and appropriate heat treatment processes, carrying out multi-pass drawing on the biomedical heating composite to product biomedical heating composite wires. The biomedical heating composite prepared by using the preparation method is good in composite interface controllability, has the excellent performances of biocompatibility and heating stability, gives full play to the biocompatibility of the titanium or titanium alloy as well as high strength and corrosion resistance of nichrome, is high in electric resistance, can achieve multiple functional characteristics, such as vibration under the electromagnetic action and can be applied to the biomedical field and suitable for industrial production.