The present invention discloses a production method of hydrolysis resistance regenerating resin synthetic leather, including: stirring uniformly and filtering dimethylformamide and wet hydrolysis resistance paste; adding a mixture of dimethylformamide, a wet hydrolysis resistance additive and a surfactant and stirring uniformly, adding wet high hydrolysis resistance regeneration polyurethane resin to mix uniformly, filtering and defoaming to get a coating; stirring the dimethylformamide and the high hydrolysis resistance regeneration polyurethane resin uniformly and then adding the mixture of the surfactant, dimethylformamide and the wet hydrolysis resistance paste to stir uniformly to get an immersion liquid, feeding non-woven fabrics in the immersion liquid and then feeding into a quantitative roll, scraping the coating, solidifying to be film, extruding and washing, drying and fixing the shape, processing the color to get the wet base, uniformly scraping the high hydrolysis resistance dry polyurethane resin, dimethylformamide, toluene, butanone, dry hydrolysis resistance paste and the surfactant on release paper, and adhering the wet base to get the product. The synthetic leather of the present invention is soft in hand feel, good in flexibility, good in touch sense, and high in peel strength.