The invention discloses a preparation method for a 110Kv and above semiconductive chemical crosslinking shielding material. The preparation method is realized through the following steps: (1), a plurality of raw materials are independently fed into a plurality of totally-enclosed vacuum feed devices for raw material mixing; (2), the mixed raw materials are conveyed to a reciprocating-type single screw machine for melt extrusion, and the shielding material is prepared after water ring pelleting is conducted; (3), the prepared shielding material is conveyed to a transition bunker in a constant-temperature state; and (4), the shielding material in the transition bunker is subjected to post-absorption treatment and discharged. The invention further discloses totally-enclosed equipment adopted by the preparation method. According to the method, the raw materials are kept at high purity in the whole process; no impurity exists in the shielding material; filter devices can be arranged at multiple places of the equipment; and the shielding material can reach a 110Kv and above voltage resistance level.