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发明授权
CN103045544B 预防西尼罗河病毒的重组假型杆状病毒Bac-G-prM/E及疫苗与应用 失效 - 权利终止

预防西尼罗河病毒的重组假型杆状病毒Bac-G-prM/E及疫苗与应用
摘要：
本发明属于动物病毒学和动物基因工程技术领域，具体涉及一种表达西尼罗河病毒prM蛋白和E蛋白的重组假型杆状病毒Bac-G-prM/E的构建、疫苗制备及应用。本发明得到一种表达西尼罗河病毒prM蛋白和E蛋白的重组假型杆状病毒Bac-G-prM/E，该重组假型杆状病毒保藏在中国典型培养物保藏中心(CCTCC)保藏号为CCTCC NO：V201130。本发明还公开了重组假型杆状病毒的制备及在制备预防西尼罗河病毒疫苗中的应用。本发明为预防西尼罗河病毒提供了新型基因工程疫苗。
摘要（英）：

The invention relates to the construction, vaccine preparation and application of a recombinant pseudotyped baculovirus Bac-G-prM/E for expressing the prM protein and E protein of a West Nile virus and belongs to the technical field of animal virology and animal genetic engineering. The invention discloses a recombinant pseudotyped baculovirus Bac-G-prM/E for expressing the prM protein and E protein of the West Nile virus, and the recombinant pseudotyped baculovirus with the preservation number of CCTCC (China Center for Type Culture Collection) NO:V201130 is preserved in the CCTCC. The invention also discloses a preparation method of the recombinant pseudotyped baculovirus and an application of the recombinant pseudotyped baculovirus in the preparation of a vaccine for preventing the West Nile virus. The invention provides a novel genetic engineering vaccine for preventing the West Nile virus.

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