The invention provides a pressurizing packer setting device capable of conducting repeated pressure setting. The setting device comprises a setting device body (1), a memory metal ring (2), a steel ball (3) and a ball connecting pipe (4) and is applicable to various pressurizing packers. The setting device is scientific in design principle, simple and ingenious in structure, convenient to install and use, high in utilization rate and low in cost, the multiple pressurizing setting function of the underground packer of an oil gas well can be performed, the production cost of about 10,000 yuan can be saved for each time, the operational timeliness of the production of the oil gas well can be improved, crude oil extraction can be prolonged by 24 hours, the direct economic benefit can achieve 20,000 yuan, the device is used for 5,000 well times per year across the country, and the economic benefit can achieve 0.15 billion yuan.