The invention discloses an active vibration isolation device with adjustable rigidity and damping. The active vibration isolation device with adjustable rigidity and damping comprises a base, a basic spring, a tubular structure, a piezoelectric ceramic actuator, a friction block, and a piezoelectric ceramic shield. The tubular structure, located inside the basic spring, and the basic spring are mounted on the base in parallel. The upper portion of the basic spring is connected with the piezoelectric ceramic shield. The upper portion of the tubular structure is connected with the piezoelectric ceramic actuator. The piezoelectric ceramic actuator is installed within the piezoelectric ceramic shield. The lateral side of the piezoelectric ceramic shield is a friction surface. A piezoelectric ceramic output shaft penetrates through a through hole of the piezoelectric ceramic shield and extends out of the friction surface. The friction block is installed at the other end of an output shaft of the actuator. The active vibration isolation device is based on the piezoelectric actuator, damping characteristic and rigidity characteristic of the active vibration isolation device can be changed simultaneously, and the active vibration isolation device is simple in structure and high in anti-jamming capability.