The invention discloses an organism for synthesizing metal organic frame based on Co(II) ion. The structural formula is shown in the specification. The invention further provides a synthesis method of the organism. The synthesis method comprises the following steps of: firstly, carrying out cyclization reaction on 3-bromine-4-methyl benzoic acid and semicarbazide hydrochloride so as to prepare a midbody A; and secondly, carrying out SuZuki reaction on the midbody A with pyridine-3-boric acid so as to prepare the organism. The invention further respectively provides three metal organic frames based on the Co(II) ion, a preparation method of the metal organic frames, and an application of the metal organic frames as an initiator in anion exchange. The organism has the beneficial effects that the compound belongs to organic-inorganic composite super-molecule materials, is simple to operate, low in cost and rapid in response, and realizes visible sensation of anions and the effective separation of the anions.