The invention discloses a detection kit and a method for predicting susceptibility to prostate cancer, belonging to the field of biotechnology. The detection kit and the method can be used for predicting susceptibility of a subject to prostate cancer by extracting the genomic deoxyribonucleic acid (DNA) of host cells and testing the genotype of the rs4714476 site near 5' end of FOXP 4 gene of the subject; when the genotype of the rs4714476 near 5' end of the FOXP 4 gene is CC or TC, the susceptibility of the subject to prostate cancer is higher; when the genotype of the rs4714476 is TT, the susceptibility of the subject to prostate cancer is the lowest; and the clinical phenotype of the prostate cancer of the subject can be predicted. The occurrence rates of neoplasm staging III and advanced prostate cancer of the patients with the genotype of CC or TC are apparently higher than those of the patients with the genotype of TT. The detection kit and the method have the advantages that the correlation between rs4714476 gene polymorphic site and prostate cancer as well as the clinical information of prostate cancer is expounded for the first time; the method for predicting the susceptibility to prostate cancer is provided; and the method can be used for early prevention diagnosis and auxiliary diagnosis of prostate cancer, and is also used for research and development of new medicines.