The invention provides a preparation method of a copper-based SnO2-Sb2O5-CeO2-TiO2 inert composite anode material. The preparation method comprises the following steps of: pretreating a copper-based material by using an industrial alkaline degreaser; and preparing the copper-based SnO2-Sb2O5-CeO2-TiO2 inert composite anode material through electrodeposition, wherein the inert composite anode material is gray with the thickness of 100 to 150 microns, excellent in bonding force and smooth and compact in crystallization. By adopting the preparation method, anode dissolved matters are prevented from polluting a cathode chrome plated layer, and the quality of a cathode product is improved; antimony pentoxide with high catalytic activity and electrical conductivity is added, so that the catalytic activity of the electrode material is improved, the bath voltage during electroplating can be effectively reduced by 0.2 to 0.4 V, and the electricity consumption is reduced; the added titanium dioxide can effectively inhibit trivalent chromium from being oxidized into hexavalent chromium during electroplating, so that the stability of a plating solution is greatly improved, and the service life of the plating solution is prolonged; and the added nano rare earth oxide plays a role in thinning grains, so that the plated layer is smooth and compact, and the corrosion resistance of the anode material is effectively improved.