The invention discloses a production process of sterilizing and mite-removing down. The method comprises the steps of: pre-grading, dust removing, fine grading, pre-washing, washing, rinsing, primary dehydrating, soaking, secondary dehydrating, and bake-drying, such that a down finished product is obtained. In the rinsing step, washed down semi-finished product is boiled for 10-15min in boiling water; the product is fetched and is soaked for 5-10min by using 10-15% hydrogen peroxide; and the product is cleaned by rinsing by using clear water. In the soaking process, 1/4 or 1/5 of the dehydrated down semi-finished product is soaked for 4-6h in a traditional Chinese medicine liquid, wherein the temperature of the traditional Chinese medicine liquid is 30-40 DEG C. The traditional Chinese medicine liquid comprises the raw materials of, by weight, 13-17 parts of kirilow rhodiola root and rhizome, 13-17 parts of mint, 13-17 parts of sessile stemona root tuber, 8-12 parts of golden thread, 8-12 parts of indigo, 6-10 parts of wrinkled gianthyssop herb, and a proper amount of water. The traditional Chinese medicine liquid adopted by the invention employs sterilizing and mite-removing traditional Chinese medicines. When dehydrated down semi-finished product is soaked in the traditional Chinese medicine liquid, traditional Chinese medicine essence is impregnated into the down, such that the down is provided with both warm-keeping and sterilizing and mite-removing functions.