The invention relates to a preparation method of oxidized pellets with coarse-grain hematite as a main raw material. The technical scheme of the invention is as follows: uniformly mixing 60-70 percent by weight of coarse-grain hematite, 20-30 percent by weight of fine-grain iron-containing raw material, 2-6 percent by weight of organic binding agent and 5-8 percent by weight of water, and carrying out pressure forming to obtain ellipsoidal green-balls; and roasting the ellipsoidal green-balls at 1150-1200 DEG C for 15-30min to obtain the oxidized pellets, wherein the coarse-grain hematite is ground hematite or pelletized return fines and has the grain diameter of being less than or equal to 6mm; the fine-grain iron-containing raw material is electric precipitation dust in the smelting process of iron ore concentrate or steel; the organic binding agent is prepared by mixing starch, inorganic sodium salt, borate and water according to a mass ratio of 1: (0.04-0.15): (0.02-0.10): (4.0-5.0); and forming equipment is a double-roll ball press machine, wherein the forming pressure is 10-30MPa. The preparation method disclosed by the invention has the advantages of strong adaptability to raw material granularity, simple process, low energy consumption, low production cost and high quality of oxidized pellets.