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发明公开
CN103079590A 使用α-二羰基化合物制备类毒素的方法 无效 - 撤回

使用α-二羰基化合物制备类毒素的方法
摘要：
本发明涉及使用如乙二醛、丁二酮和苯甲酰甲醛等α-二羰基类毒素化试剂制备的类毒素的应用。所述类毒素可以用低浓度的类毒素化试剂在短的时间内、通常在少至24小时中制得，使得所述类毒素化试剂在与传统甲醛类毒素化相比时特别有利。本发明描述了使用如苯甲酰甲醛等二羰基试剂制得的类毒素，并要求保护包含所述类毒素的药物和疫苗组合物，使用此类组合物的治疗方法和通过用所述类毒素免疫接种产生的抗体以及使用如此制备的抗体的治疗方法或此类抗体的片段。
摘要（英）：

The present invention relates to the use of toxoids prepared using a-dicarbonyl toxoiding reagents such as glyoxal, butanedione and phenylglyoxal. The toxoids may be prepared with low concentrations of toxoiding reagent and in short periods of time, often in as few as 24 hours, making the toxoiding reagents particularly advantageous when compared with traditional formaldehyde toxoiding. Toxoids prepared using dicarbonyl reagents such as phenylglyoxal are described and claimed as are pharmaceutical and vaccine compositions comprising the toxoids, methods of treatment using such compositions and antibodies generated by immunisation with the toxoid and methods of treatment using the antibodies so prepared or fragments of such antibodies.

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