The invention discloses a lumbrukinase compound fertilizer. The lumbrukinase compound fertilizer comprises the following components in percentage by weight: a basic chemical fertilizer, 11.7-49.0% of an anti-freezing agent, 1.6-12.0% of lumbrukinase and 1.7-15.0% of a synergist. A method for preparing the lumbrukinase compound fertilizer comprises the following steps of: A, crushing raw materials, metering and uniformly mixing; B, granulating; C, screening, drying, cooling and re-screening; D, enveloping; and E, metering and packaging. The obtained lumbrukinase compound fertilizer is environment-friendly, and after the lumbrukinase compound fertilizer is applied for a long time, the granular structure of soil can be effectively improved, soil hardening is eliminated, and the infiltration capacity of the soil is improved; the buffer performance of the soil is improved, so that the harm of soil secondary salinization caused by excess fertilization to crops can be relieved; the growth and development of beneficial microorganisms in the soil are promoted, so that the utilization rate of the fertilizer is improved; and the growth of crop roots is promoted, so that the crop roots are developed, the disease resistance of crops is improved, and the crop yield is obviously increased.