The invention provides a touch display screen and a driving method of the touch display screen and relates to the field of display techniques. An interactive touch display screen capable of enabling a user to have touch sensation can be built. The touch display screen comprises a detection module, an conducting layer and a peripheral circuit, wherein the detection module is used for real-time detection of a current touch position, the conducting layer is arranged on the surface of a touch panel of the touch display screen and positioned in a display area of the touch panel, and the peripheral circuit is arranged in a non-display area of the touch panel, connected with the conducting layer, and load the conducting layer with a voltage, and a current is generated on a touch object contacting the touch display screen by the loaded voltage.