The invention relates to a pharmaceutical composition which comprises dapoxetine or a medicinal salt thereof, a phosphodiesterase inhibitor (PDE) and pharmaceutically acceptable adjuvants. The pharmaceutical composition provided by the invention can be used for treating premature ejaculation, impotence or coexisting premature ejaculation and impotence, has the characteristics of a good effect, small dosage, a few side effects and the like and has a good practical value.