The invention relates to a self-cleaning high-salt wastewater evaporative crystallization device. The evaporative crystallization device comprises a heater (1), an injection pump (3), a self-cleaning medium (4), a solid-liquid separating chamber (5), an evaporative crystallization chamber (6), a steam compressor (7), a strong brine pump (8) and a material water pump (9). By adopting the evaporative crystallization device, because the self-cleaning medium flows continuously in a heat transfer pipe of the heater and rubs and crashes the inner wall of the heat transfer pipe continuously, the dirt deposited on the inner wall of the heat transfer pipe is peeled off, and the self-cleaning medium is drained out of a heating chamber together with the material water, and thus the purpose of self-cleaning of the device is achieved; with the adoption of the evaporative crystallization device, the problem of scaling of the heat transfer pipe can be solved, and thus the heat transfer deterioration of the heat transfer pipe can be avoided, the heating exchanging property of the heater is enhanced, the usage rate of the wastewater evaporative crystallization device is improved, the work load of on-site maintenance is reduced, the dosage of chemicals is reduced, and meanwhile the pressure of environment pollution is reduced; and the wastewater evaporative crystallization is simple in structure, low in machining and manufacturing cost, and easy and convenient to mount and demount.