The invention discloses a demolding device of an explosion-proof pressing machine for pressing liquid medicine. The demolding device comprises a bottom plate which is fixedly mounted on the plane on a sliding block of the explosion-proof pressing machine for pressing the liquid medicine, wherein guide tracks are respectively arranged on the front side and the back side of the bottom plate, a structural member with the bottom adopting a comb tooth-shaped structure is mounted on the guide tracks in a sliding manner, a pressing block adopting an integral structure is fixedly arranged on a plurality of comb teeth at the bottom of the structural member for forming a pressing working position, and demolding working positions are formed between the adjacent comb teeth; a driving oil cylinder is mounted on a frame plate on the right side edge of the bottom plate, and a piston rod of the driving oil cylinder is fixedly connected with the structural member with the bottom adopting the comb tooth-shaped structure; and a left stroke-limiting jackscrew and a right stroke-limiting jackscrew are respectively mounted on side frames on the left side and the right side of the bottom plate, and the left and the right stroke-limiting jackscrews are used for limiting the limit positions of left-and-right movement of the structural member. The demolding device disclosed by the invention can realize automatic demolding of a medicine column after press-forming, and the automatic operation can enable the operation staff to be far away from dangerous equipment, so that the intrinsic safety of the operation staff can be realized and the production efficiency can be simultaneously improved.