The invention discloses a high temperature and high pressure test packer. The high temperature and high pressure test packer comprises a hydraulic anchor, a rubber sleeve, a mechanical slip, a friction assembly, and a core shaft, wherein one end of the core shaft is connected with the hydraulic anchor through screw threads, and the rubber sleeve, the mechanical slip and the friction assembly which are installed on the core shaft are arranged in sequence between the hydraulic anchor and the other end of the core shaft. A volume pipe is inserted in the hydraulic anchor and the core shaft, the rubber sleeve comprises a rubber sleeve body, and the rubber sleeve body comprises a head end rubber sleeve body, a middle portion rubber sleeve body and a tail end rubber sleeve body, wherein the head end rubber sleeve body, the middle portion rubber sleeve body and the tail end rubber sleeve body are in an integrated structure, and the hardness of the head end rubber sleeve body and the tail end rubber sleeve body is higher than the middle portion rubber sleeve body. The high temperature and high pressure test packer is capable of effectively separating an oil sleeve, improving test differential pressure and enlarging a pressure control window for test operation and beneficial to releasing reservoir pressure. The high temperature and high pressure test packer is of great importance to improving the test success rate and reducing operating risks.