The invention discloses silicone dressing, and a preparation method and the use thereof. The silicone dressing is prepared from silicone, an organosilicon antibacterial agent, and matrix. The silicone dressing is reasonable in formula and convenient to prepare, can effectively restrain various hyperplastic scars caused by the reasons of burn, trauma, surgery, infection and the like, protects various wound surfaces caused by the reasons of burn, trauma, surgery, infection and the like, controls wound surface infection, keeps the wound surface wet, and promotes the wound surface to heal. The effective rate achieves over 95% by validation of more than 100 clinical cases; and the bacteriostatic ability of the product on staphylococcus aureus and escherichia coli can be over 99%.