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发明公开
CN103130805A 多尼培南中间体溶剂化物 有权 转让

多尼培南中间体溶剂化物
摘要：
本发明涉及一种式2所示的多尼培南中间体乙醇化物，其制备方法及其应用。本发明的多尼培南中间体乙醇化物性质稳定，易于保存，纯度高，为后续氢化脱保护反应奠定了基础，所述乙醇化物制备方法操作简单，所用结晶试剂为乙醇，对人体健康及环境危害较小，适宜工业生产。
摘要（英）：

The invention relates to a Doripenem intermediate alcoholate shown as a formula 2 and a preparation method and application of the Doripenem intermediate alcoholate. Doripenem intermediate alcoholate is stable in property, easy to preserve, and high in purity, and establishes a foundation for a following hydrogenating deprotection reaction. The preparation method of the alcoholate is simple in operation, and a used crystallization reagent is ethanol which is less harmful to human health and environment, and the preparation method is suitable for industrial production.

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